Two of the most prevalent instruments in any analytical chemistry lab are a GCMS and HPLC instrument setups. Both can be used to perform the same tests, although there are some fundamental differences between the testing methods, as well as noticeable differences in accuracy depending on the solution being analyzed.
Below are two videos from the YouTube channel of MrSimpleScience that describe how each testing method works, providing a high-level overview of the processes involved as well as the basics of working with these tests.
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HPLC stands for high-performance liquid chromatography. This method of testing has a wide variety of applications ranging from manufacturing to medical analysis. It is the most common method of testing due to its versatility. Please watch this video from MrSimpleScience to gain a high-level overview of how the HPLC process works!
GC-MS Testing – How It Works
GC-MS stands for gas chromatography-mass spectrometry. It is another method for analytical chemists to use to identify substances within a sample, but works differently than HPLC methods. Rather than using liquid as the mobile phase, GC is used to test samples of volatile substances that can be “dissolved” into gas. There are specific instances where GC is preferred over HPLC, although with advances in HPLC instrumentation that gap is closing.